Hemichannels: new roles in astroglial function
نویسندگان
چکیده
منابع مشابه
Hemichannels: new roles in astroglial function
The role of astrocytes in brain function has evolved over the last decade, from support cells to active participants in the neuronal synapse through the release of "gliotransmitters."Astrocytes express receptors for most neurotransmitters and respond to them through Ca(2+) intracellular oscillations and propagation of intercellular Ca(2+) waves. While such waves are able to propagate among neig...
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Fast exchange of extracellular signals between neurons and astrocytes is crucial for synaptic function. Over the last few decades, different pathways of astroglial release of neuroactive substances have been proposed to modulate neurotransmission. However, their involvement in physiological conditions is highly debated. Connexins, the gap junction forming proteins, are highly expressed in astro...
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Under physiological conditions, astroglial hemichannels and pannexons allow the release of gliotransmitters from astrocytes. These gliotransmitters are critical in modulating synaptic transmission, plasticity and memory. However, recent evidence suggests that under pathological conditions, they may be central in the development of various neurodegenerative diseases. Here we review current liter...
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INTRODUCTION Coordinated cell interactions are required to accomplish diverse complex and dynamic tasks of several tissues in vertebrates and invertebrates. Cell functions, such as intercellular propagation of calcium waves and spread of electrotonic potentials, are coordinated by cell-to-cell communication through gap junction channels (GJCs). These channels are formed by the serial docking of...
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ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2014
ISSN: 1664-042X
DOI: 10.3389/fphys.2014.00193